Studies done by scientists from Imperial College London say that the longstanding theory of how HIV slowly depletes the body's capacity to fight infection is not correct! Excerpts from BBC Aids Logo from Bioblog.ITHIV attacks human immune cells, called T helper cells. Loss of these cells is gradual, often taking many years.
It was thought infected cells produced more HIV particles and that this caused the body to activate more T cells which in turn were infected and died.
Imperial College London modelling suggests that, if that was true, cells would die out in months not years.
The imperial team used a mathematical model of the processes by which T cells are produced and eliminated.
Using this they showed that the current theory of an uncontrolled cycle of T cell activation, infection, HIV production and cell destruction - dubbed the "runaway" hypothesis - was flawed.
They concluded that it could not explain the very slow pace of depletion that occurs in HIV infection.
They showed that if the theory was correct, then T helper cell numbers would fall to very low levels over a number of months, not years.
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